Allele appearnce

The group of IGHV1-2 includes 7 alleles, 7 out of the alleles are functional.

For each allele we counted the number of appearances across the population, any appearance was considered valid.

Group alignment

Based on the viewd alleles, we calculated the distance between the germline sequences.

Sequence depth

To examine the potential cutoff we observed the sequence depth for each allele

0.5% cutoff

We set an initial cutoff of \(0.5\%\) to determine the potential genotype priors. For this cutoff we examined the zygousity state, such as homozygousity, heterozygousity and so on.

With the selected cutoff we saw that there are 4 zygousity states.

Observations

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[1] TRUE

Conclusions

From the results we belive that the cutoff for this group should be closer to \(2\%\), and for the adjusted states the allele combinations and the relations are stated in the table below.

For interactive play on the threshold and relative allele fractions, please refer to this site